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Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
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research activity
  • oligosaccharide synthesis
  • neoglycoconjugates
  • glycoarrays
  • supramolecular chemistry
  • influenza
  • transplantology and blood groups
  • oncology
  • natural antibodies
  • glycotargeting
    1. Antibodies to Galβ1-3GlcNAc (LeC) disaccharide found to have high titers in practically all healthy donors. In breast cancer patients its level is significantly reduced, therefore we supposed that the antibody play a role of housekeepers for elimination of cancer cells. Isolated monospecific anti-LeC specifically stained breas cancer cells. In 2017 we started project directed to application of the antibodies as anti-cancer therapeutic.
    2. Printed glycan array allows us to find in blood of cancer patients diagnostically relevant anti-glycan natural antibodies (diagnostic signature) for revealing of breast, ovarian and colorectal cancers.
    3. Supposing that a tumor is an inflammation site, selectin ligand SiaLex was used as specific vector (lipophilic form of the tetrasaccharide) for delivery of cytotoxic liposomes to tumor. Indeed, such liposomes caused drastic increase in life time of mice with grafted tumors, even in case of single preparation administration.
    The role of carbohydrate chains in phagocytosis of apoptotic bodies obtained from melanoma cell line has been studied on a model where macrophage cell line was used. It was shown that termination Galβ1-3GalNAcβ is the specific component of apoptotic bodies surface during phagocytosis, whereas the specific component of phagocyting cells is, possibly, galectin-1. Moreover, synthetic lipophilic variant of the disaccharide built in apoptotic bodies and administered to experimental mice caused phagocytosis increase and elevated vitality of animals with experimental tumors.